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Gastroesophageal reflux and esophagitis are frequently related to delayed stomach emptying:
- Upper abdominal pain, feeling of abdominal distension, and epigastric fullness
- Eructation, flatulence, and early satiety are all symptoms of early satiety.
- Vomiting and nausea
- Regurgitation of stomach contents into the mouth, with or without heartburn
- Dyspepsia without ulcers
- Acute nausea and vomiting of functional, organic, infectious, or dietetic origin, as well as nausea and vomiting generated by radiotherapy or pharmacological therapy, and nausea and vomiting induced in migraine.
- Dopamine agonist-induced nausea and vomiting in Parkinson's disease.
- Increasing the speed of barium transit in follow-up radiological tests.
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বাহিরে
✅ Description:
Domperidone may be a dopamine opponent that principally pieces the dopamine receptors found within the ChemoreceptorTrigger Zone (CTZ) and stomach. Its gastroprokinetic activity is based on its blocking impact of dopamine receptors that have an impact on the motility of the gastrointestinal tract. Due to its frail entrance over the blood-brain barrier, Domperidone has nearly no impact on the dopaminergic receptors within the brain, in this manner, barring psychotropic and neurologic side impacts. Domperidone reestablishes typical motility and tone of the upper gastrointestinal tract, encourages gastric purging, upgrades antral and duodenal peristalsis, and directs withdrawal of the pylorus. Domperidone too increments esophageal peristalsis and lower esophageal sphincter weight, and hence anticipates spewing forth of gastric content.
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✔️ The usual recommended oral dose of Domperidone is as follows:
General Recommended Dose
- Adults: 10–20 mg (1–2 tablets or 10–20 ml suspension) every 6–8 hours.
- Maximum daily dose: 80 mg.
Children: 2–4 ml suspension per 10 kg body weight
OR 0.4–0.8 ml pediatric drops per 10 kg body weight, every 6–8 hours.
For Dyspeptic Symptoms
- Adults: 10–20 mg (1–2 tablets or 10–20 ml suspension) every 6–8 hours.
Children: 0.2–0.4 mg/kg body weight (equivalent to 2–4 ml suspension/10 kg or 0.4–0.8 ml pediatric drops/10 kg) every 6–8 hours.
For Acute & Sub-acute Conditions
(Primarily in acute nausea and vomiting)
- Adults: 20 mg (2 tablets or 20 ml suspension) every 6–8 hours.
Children: 0.2–0.4 mg/kg body weight (2–4 ml suspension/10 kg or 0.4–0.8 ml pediatric drops/10 kg) every 6–8 hours.
✔️ Side Effects
Hyperprolactinemia is a side effect of domperidone (1.3 percent ). Galactorrhea, breast growth, discomfort, and a decrease in libido are all possible side effects. During domperidone treatment, dry mouth (1 percent), thirst, headache (1.2 percent), nervousness, drowsiness (0.4 percent), diarrhea (0.2 percent), skin rash, and itching (0.1 percent) are all possible side effects. Clinical investigations show that extrapyramidal responses occur in 0.05 percent of patients.
✔️ Interaction
Domperidone may reduce the risk of the hypoprolactemic effect of bromocriptine. The action of Domperidone on Gl function may be antagonized by antimuscarinics and opoid analgesics. Care should be exercised when domperidone is administered in combination with MAO (monoamine oxidase) inhibitors.
✔️ Contraindications:
Domperidone may reduce the risk of the hypoprolactemic effect of bromocriptine. The action of Domperidone on Gl function may be antagonized by antimuscarinics and opoid analgesics. Care should be exercised when domperidone is administered in combination with MAO (monoamine oxidase) inhibitors.
✔️ Pregnancy & Lactation
Because the safety of domperidone has not been established, it is not recommended for use during pregnancy. The teratogenic effect in the fetus has not been shown in animal research. Domperidone can help with galactorrhea and postpartum lactation. It's secreted in breast milk, but in such small amounts that it's not considered dangerous.
✔️ Precautions & Warnings
Domperidone should be used with extreme caution in children due to an elevated risk of extrapyramidal effects, due to an incompletely established blood-brain barrier in young children. Domperidone should be taken with caution in patients with hepatic impairment since it is highly metabolized in the liver.
✔️ Storage:
Store at or below 30°C, away from light and moisture. Keep out of reach of youngsters.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
